Prospective Randomized Comparison of OnabotulinumtoxinA (Botox) and AbobotulinumtoxinA (Dysport) in the Treatment of Forehead, Glabellar, and Periorbital Wrinkles

Botulinum toxin A, a neurotoxic protein produced by Clostridium botulinum, is being utilized by clinicians to decrease muscle hyperactivity for a multitude of therapeutic and cosmetic symptoms ranging from cervical dystonia to glabellar rhytids. Its use accounted for more than 25% of nonsurgical aesthetic procedures in the United States in 2008.1 There are eight serotypes of the toxin, synthesized as a single-chain polypeptide protoxin and “nicked” by proteases to activate binding at nerve terminal receptors. Once bound to synaptic receptor SNAP-25, the toxin inhibits release of acetylcholine, thus causing muscle paralysis.

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